Table 2.
Univariate and multivariate analysis of the overall survival in ESCC
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Gender | ||||
| Female vs. male | 0.713 (0.369–1.377) | 0.314 | ||
| Age | ||||
| < 60 vs. ≥ 60 | 0.604 (0.337–1.081) | 0.090 | ||
| Lymph node metastasis | ||||
| Negative vs. positive | 0.377 (0.206–0.687) | 0.001* | 0.425 (0.225–0.802) | 0.008* |
| Depth of invasion | ||||
| T1–T2 vs. T3–T4 | 0.531 (0.287–0.981) | 0.043* | 0.513 (0.274–0.960) | 0.051 |
| Differentiation | ||||
| Well vs. moderately/poorly | 3.425 (1.546–7.586) | 0.002* | 0.403 (0.173–0.940) | 0.035* |
| Tumor size | ||||
| < 4 cm vs. ≥ 4 cm | 1.564 (0.869–2.815) | 0.136 | ||
| Vascular invasion | ||||
| Negative vs. positive | 2.011 (0.967–4.050) | 0.058 | ||
| MLL2 expression | ||||
| Low vs. high | 2.085 (1.163–3.736) | 0.014* | 0.601 (0.324–1.115) | 0.089 |
*Statistically significant (P < 0.05)
HR hazard ratio, CI confidence interval