Fig. 3.

Identity of Nestin⁺ cells found in neural tissues and bone marrow. The main subsets of Nestin⁺ cells present in neural-related tissues (brain, cerebellum, retina, gut, skin) and bone marrow are shown. These subsets comprise neural stem cells, neural progenitor cells, astrocytes, radial glia-like precursors, subsets of glia cells with regenerative potential, several types of neural precursor cells outside brain, pericytes, mesenchymal stromal cells, endothelial cells, and Schwann cell precursors. They are distinct in their location, functional properties and co-expression of selective markers. Nestin⁺ cells are represented in green. In brain and bone marrow, Nestin-gfp^bright and gfp^dim cells have been described according to gfp intensity levels in Nestin-gfp mice. NSC neural stem cells, NPC neural progenitor cell, MSC mesenchymal stromal cell, Gfap glial fibrillary acidic protein, SOX2 sex determining region Y-box 2, p75 NTR p75 neurotrophin receptor, NG2 neural/glial antigen 2, Leptin R leptin receptor