Table 3.
Multivariate Cox Regression for the whole cohort, the Right-sided cohort and the Left-sided cohort
| Patients Characteristics | Full cohort | Right-sided | Left-sided | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| Age at diagnosis | < 0.001 | < 0.001 | < 0.001 | |||
| < 40 | 1.000 | 1.000 | 1.000 | |||
| 40–49 | 1.074 (0.962–1.199) | 0.201 | 1.019 (0.875–1.187) | 0.809 | 1.146 (0.977–1.343) | 0.094 |
| 50–59 | 1.144 (1.035–1.264) | .0.008 | 1.162 (1.014–1.333) | 0.031 | 1.107 (0.956–1.281) | 0.174 |
| 60–69 | 1.466 (1.330–1.616) | < 0.001 | 1.422 (1.245–1.624) | < 0.001 | 1.462 (1.266–1.688) | < 0.001 |
| > 70 | 2.516 (2.287–2.769) | < 0.001 | 2.265 (1.987–2.581) | < 0.001 | 2.878 (2.500–3.312) | < 0.001 |
| Sex | ||||||
| Female vs. Male | 0.804 (0.784–0.825) | < 0.001 | 0.796 (0.762–0.833) | < 0.001 | ||
| Race | < 0.001 | < 0.001 | < 0.001 | |||
| Black | 1.000 | 1.000 | 1.000 | |||
| White | 0.866 (0.834–0.898) | < 0.001 | 0.907 (0.866–0.950) | < 0.001 | 0.797 (0.749–0.848) | < 0.001 |
| Hispanic/Latino | 0.848 (0.718–1.001) | 0.051 | 0.856 (0.696–1.052) | 0.140 | 0.825 (0.625–1.090) | 0.175 |
| Asian or Pacific Islander and others | 0.687 (0.647–0.729) | < 0.001 | 0.699 (0.646–0.757) | < 0.001 | 0.663 (0.606–0.726) | < 0.001 |
| Unknown | 0.471 (0.339–0.654) | < 0.001 | 0.482 (0.317–0.734) | 0.001 | 0.462 (0.273–0.783) | 0.004 |
| Hispanic | ||||||
| Yes vs. No | 0.920 (0.881–0.962) | < 0.001 | 0.906 (0.857–0.958) | < 0.001 | ||
| T stage | < 0.001 | < 0.001 | ||||
| T0-T2 (0, 2, 3) | 1.000 | 1.00 | 1.000 | |||
| T3-T4 (4, 5) | 1.703 (1.629–1.780) | < 0.001 | 1.540 (1.458–1.627) | < 0.001 | 1.984 (1.841–2.138) | < 0.001 |
| TX (6) | 1.366 (0.933–1.999) | 0.109 | 1.155 (0.693–1.926) | 0.580 | 1.756 (0.991–3.112) | 0.054 |
| N stage | ||||||
| N2 vs. N1 | 1.139 (1.097–1.181) | < 0.001 | 1.157 (1.105–1.211) | < 0.001 | 1.063 (1.005–1.124) | 0.033 |
| Chemotherapy | ||||||
| Yes vs. No | 0.499 (0.486–0.513) | < 0.001 | 0.501 (0.485–0.517) | < 0.001 | 0.491 (0.469–0.513) | < 0.001 |
| Radiotherapy | < 0.001 | |||||
| No | 1.000 | 1.000 | 1.000 | |||
| Yes | 1.286 (1.017–1.626) | 0.036 | 1.402 (1.031–1.906) | 0.031 | 1.253 (0.865–1.816) | 0.233 |
| Unknown | 0.866 (0.696–1.077) | 0.196 | 0.851 (0.644–1.123) | 0.254 | 0.886 (0.623–1.262) | 0.503 |
| Marital status | < 0.001 | < 0.001 | < 0.001 | |||
| Single, separated, divorced, | 1.000 | 1.000 | 1.000 | |||
| Married (including common law) | 0.785 (0.761–0.811) | < 0.001 | 0.844 (0.811–0.878) | < 0.001 | 0.733 (0.695–0.773) | < 0.001 |
| Windowed | 1.078 (1.039–1.120) | < 0.001 | 1.051 (1.005–1.099) | < 0.001 | 1.029 (0.963–1.099) | 0.399 |
| Unknown | 0.875 (0.818–0.936) | < 0.001 | 0.904 (0.834–0.981) | 0.015 | 0.812 (0.720–0.916) | 0.001 |
| Pathology grade | < 0.001 | < 0.001 | < 0.001 | |||
| Well-differentiated | 1.000 | 1.000 | 1.000 | |||
| Moderately differentiated | 1.086 (1.025–1.151) | 0.005 | 1.145 (1.063–1.233) | < 0.001 | 1.003 (0.915–1.101) | 0.942 |
| Poorly differentiated | 1.340 (1.262–1.424) | < 0.001 | 1.378 (1.276–1.487) | < 0.001 | 1.282 (1.160–1.417) | < 0.001 |
| Undifferentiated | 1.636 (1.507–1.777) | < 0.001 | 1.658 (1.502–1.830) | < 0.001 | 1.639 (1.393–1.928) | < 0.001 |
| Unknown | 1.228 (1.115–1.352) | < 0.001 | 1.275 (1.133–1.435) | < 0.001 | 1.157 (0.979–1.368) | 0.087 |
| Tumor site | ||||||
| Left-sided vs. Right-sided | 0.847 (0.824–0.870) | < 0.001 | ||||
| Lymph nodes ratio | < 0.001 | < 0.001 | < 0.001 | |||
| < 0.07 | 1.000 | 1.000 | 1.000 | |||
| 0.07–0.25 | 1.277 (1.229–1.325) | < 0.001 | 1.294 (1.236–1.354) | < 0.001 | 1.245 (1.167–1.328) | < 0.001 |
| 0.25–0.50 | 1.602 (1.523–1.685) | < 0.001 | 1.663 (1.563–1.770) | < 0.001 | 1.514 (1.402–1.636) | < 0.001 |
| 0.50–1.0 | 2.494 (2.357–2.640) | < 0.001 | 2.671 (2.491–2.863) | < 0.001 | 2.282 (2.100–2.480) | < 0.001 |
| aTotal number of lymph nodes (without Lymph nodes ratio) | ||||||
| ≥ 12 vs. < 12 | 0.747 (0.728–0.766) | < 0.001 | 0.706 (0.683–0.730) | < 0.001 | 0.780 (0.747–0.815) | < 0.001 |
| Total number of lymph nodes (with Lymph nodes ratio) | ||||||
| ≥ 12 vs. < 12 | 0.938 (0.909–0.967) | < 0.001 | 0.902 (0.886–0.957) | < 0.001 | 0.968 (0.919–1.020) | 0.223 |
| bTotal number of lymph nodes (without Lymph nodes ratio) | 1.000 (0.998–1.001) | 0.694 | 0.981 (0.980–0.983) | < 0.001 | 0.985 (0.982–0.987) | < 0.001 |
| Total number of lymph nodes (with Lymph nodes ratio) | 1.004 (1.003–1.006) | < 0.001 | 0.994 (0.992–0.997) | < 0.001 | 0.996 (0.993–1.000) | 0.033 |
| cTotal number of lymph nodes (without Lymph nodes ratio) | ||||||
| ≥ 11 vs. < 11 | 0.704 (0.669–0.740) | < 0.001 | ||||
| Total number of lymph nodes (with Lymph nodes ratio) | ||||||
| ≥ 11 vs. < 11 | 0.868 (0.813–0.927) | < 0.001 | ||||
Abbreviations: aTotal number of lymph nodes as a Categorical variable
bTotal number of lymph nodes as a continuous variable
cThe threshold is 11 in the Left-sided cohort