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. 2018 May 11;19:76. doi: 10.1186/s12881-018-0593-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Conservation of FAM20C (p.Ser410Thr) residue in various orthologs: (a) The multiple alignment of the protein sequence region surrounding the variant c.1228 T > A (p.Ser410Thr) against various orthologous sequences. The conserved Serine (S) residue in all the orthologs is mark red. b The phylogenetic tree depicting the evolutionary conservation of FAM20C gene in various orthologs