Table 1.
Association of STAT1 Expression with Clinicopathological Features of Patients with Epithelial-Type Ovarian Tumors
| Clinicopathological features |
Age | pSTAT1-Y701 | pSTAT1-S727 | STAT1 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | M (Md) | + (%) | - (%) | P-value | + (%) | - (%) | P-value | + (%) | - (%) | P-value | |
| Age at diagnosis | 0.429 | 0.579 | 0.236 | ||||||||
| ≤ 45 | 25 | 39 (33) | 6 (24) | 19 (76) | 9 (36) | 16 (64) | 8 (28) | 17 (72) | |||
| > 45 | 48 | 66 (53) | 14 (29) | 34 (71) | 17 (35) | 31 (65) | 21 (41) | 27 (59) | |||
| Histological type of tumor | 0.287a | 0.455b | 0.066c | ||||||||
| Serous | 0.065d | 0.747e | 0.173f | ||||||||
| Benign | 4 | 42 (42) | 1 (25) | 3 (75) | 2 (50) | 2 (50) | 0 (0) | 4 (100) | |||
| Borderline | 5 | 38 (34) | 4 (80) | 1 (20) | 3 (60) | 2 (40) | 2 (40) | 3 (60) | |||
| Malignant | 27 | 48 (50) | 7 (26) | 20 (74) | 11 (41) | 16 (59) | 14 (52) | 13 (48) | |||
| Mucinous | 0.333g | 0.706h | 0.333i | ||||||||
| Benign | 8 | 35 (32) | 1 (13) | 7 (87) | 2 (25) | 6 (75) | 1 (13) | 7 (87) | |||
| Borderline | 2 | 37 (37) | 1 (50) | 1 (50) | 1 (50) | 1 (50) | 1 (50) | 1 (50) | |||
| Malignant | 3 | 55 (63) | 0 (0) | 3 (100) | 0 (0) | 3 (100) | 0 (0) | 3 (100) | |||
| Endometrioid | |||||||||||
| Malignant | 9 | 51 (53) | 2 (22) | 7 (78) | 4 (44) | 5 (56) | 3 (33) | 6 (67) | |||
| Transitional cell | |||||||||||
| Malignant | 5 | 49 (51) | 3 (60) | 2 (40) | 1 (20) | 4 (80) | 4 (80) | 1 (20) | |||
| LN metastasis | 0.487 | 0.230 | 0.352 | ||||||||
| Yes | 10 | 52 (54) | 2 (20) | 8 (80) | 2 (20) | 8 (80.0) | 5 (50) | 5 (50) | |||
| No | 63 | 45 (48) | 17 (27) | 46 (73) | 24 (38) | 39 (62) | 24 (38) | 39 (62) | |||
| FIGO stage | 0.434j | 0.590k | 0.156l | ||||||||
| I | 24 | 50 (52) | 4 (17) | 20 (83) | 8 (33) | 16 (67) | 8 (32) | 16 (68) | |||
| II | 10 | 50 (51) | 4 (40) | 6 (60) | 5 (50) | 5 (50) | 6 (60) | 4 (40) | |||
| III | 9 | 48 (50) | 3 (33) | 6 (67) | 2 (22) | 7 (78) | 6 (67) | 3 (33) | |||
| IV | 1 | 38 (38) | 0 (0) | 1 (100) | 0 (0) | 1 (100) | 0 (0) | 1 (100) | |||
| Grade (serous) | 0.072 | 0.274 | 0.031 | ||||||||
| Low-grade | 29 | 48 (50) | 5 (17) | 24 (83) | 10 (35) | 19 (65) | 13 (45) | 16 (55) | |||
| High-grade | 5 | 52 (52) | 3 (60) | 2 (40) | 3 (60) | 2 (40) | 5 (100) | 0 (0) | |||
The expression of pSTAT1-Y701, pSTAT1-S727, and STAT1 in tissue microarray was detected by immunohistochemistry. For comparison of STAT1 protein expression associated with age, histological type, lymph node metastasis, FIGO stage and grade, Fisher’s exact test was applied. LN, lymph node; n, number of cases; M, mean; Md, median; −, negative expression; +, positive expression
a,b,c Multiple comparisons of the histological types (serous, mucinous, endometrioid, and transitional cell tumors)
d,e,fMultiple comparisons of serous tumors (benign, borderline, and malignant tumors)
g,h,iMultiple comparisons of mucinous tumors (benign, borderline, and malignant tumors)
j,k,lMultiple comparisons of the stages