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. 2018 May 12;17:88. doi: 10.1186/s12943-018-0839-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — TIGAR promotes migration and invasion of lung cancer via Met. (a) H1299 cells were cotransfected with Flag-TIGAR or empty vector (as control) plus siMET or siNC for 48h before wound-healing assay. (b) Western Blot showed the protein expression of Met and TIGAR after Met knockdown in TIGAR overexpression in H1299 cells. (c) Trans-well assay was performed experiment in A549 cells cotransfected with Flag-TIGAR (or vector as control) and siMet (or siNC as control). (d) The protein expression of Met and TIGAR after Met knockdown in TIGAR overexpression in A549 cells was detected by Western Blot