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. 2018 May 11;19:94. doi: 10.1186/s12931-018-0800-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Increased pulmonary vascular remodeling in MCT induced rats. (a) Representative micrographs of histological assessment demonstrating thickening of the pulmonary vascular (black arrow) in the PAH model group; (b) Representative micrographs of Immunostaining of lung-tissue-treated rats revealing increasing α-SMA expression in the distal pulmonary arteries (MCT, n = 5; Vehicle, n = 5). α-SMA = α-smooth muscle actin; MCT = monocrotaline (**P < 0.01)