Table 2. Top 10 HKGs with the lowest average coefficient of variation.

Among the 70 shared HKGs, these 10 genes have a CV less than 0.34 and a maximum difference in CV of 0.167 (in HYAL2) across cancer subtypes.

			Coefficient of variation
Accession number	Gene name	Official symbol	NL	AD	SCLC	SQCLC
P61077	Ubiquitin-conjugating enzyme E2 D3	UBE2D3	0.204	0.204	0.142	0.257
P61586	Transforming protein RhoA	RHOA	0.087	0.179	0.204	0.223
P27348	14-3-3 protein theta	YWHAQ	0.111	0.241	0.177	0.213
Q16531	DNA damage-binding protein 1	DDB1	0.074	0.199	0.165	0.296
Q13418	Integrin-linked protein kinase	ILK	0.191	0.229	0.260	0.193
P07910	Heterogeneous nuclear ribonucleoproteins C1/C2	HNRNPC	0.124	0.189	0.307	0.188
Q12891	Hyaluronidase-2	HYAL2	0.266	0.194	0.339	0.172
P55061	Bax inhibitor 1	TMBIM6	0.168	0.278	0.257	0.180
P50991	T-complex protein 1 subunit delta	CCT4	0.126	0.293	0.128	0.298
Q15233	Non-POU domain-containing octamer-binding protein	NONO	0.081	0.250	0.234	0.238
P01116	Kirsten rat sarcoma viral oncogene homolog	KRAS	0.240	1.027	0.330	0.262
Q9UM73	ALK receptor tyrosine kinase	ALK	2.066	5.190	1.692	10.334
P07949	ret proto-oncogene	RET	1.842	4.899	0.440	5.100
P00533	Epidermal growth factor receptor	EGFR	0.413	1.897	1.408	0.903
P08581	Hepatocyte growth factor receptor	MET	0.961	1.918	1.413	0.836
P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	PIK3CA	0.367	0.561	0.655	0.666

Notes.

^aBolded gene symbols are housekeeping genes.

TITLE

NL

Normal Lung

AD

Adenocarcinoma

SCLC

Small Cell Lung Carcinoma

SQCLC

Squamous Cell Lung Carcinoma