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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Diagn Cytopathol. 2018 Apr 16;46(6):507–515. doi: 10.1002/dc.23941

Figure 3. Illustration of nuclear envelope perturbation following lamina disruption.

Figure 3

The nuclear envelope (thin blue line) is supported by a layer of nuclear lamina (orange line). The nuclear envelope is anchored by binding to microtubules (green lines) through the Nesprin-SUN LINC bridge (yellow lines). Partial disruption of nuclear lamina produces local perturbation of the nuclear envelope. Complete loss of nuclear lamina results in a malleable nuclear envelope that deforms from pulling by force through the LINC bridges and the microtubule cytoskeleton that is organized by a centrosome (“V” like symbol).