. Author manuscript; available in PMC: 2019 Jun 1.

Published in final edited form as: Mol Genet Genomics. 2018 Jan 11;293(3):711–723. doi: 10.1007/s00438-017-1414-1

Table 1.

Pleiotropy estimated between FNK BMD and PL by GPA

LRT	FNK BMD & HDL	FNK BMD & LDL	FNK BMD & TC	FNK BMD & TG
test statistics	7.573	2.382	2.595	1.869
p value	5.92E-03	1.23E-01	1.07E-01	1.72E-01
π₀₀	9.82E-01 (2.5E-03)	9.82E-01 (2.4E-03)	9.81E-01 (2.4E-03)	9.83E-01 (2.4E-03)
π₀₁	1.55E-02 (2.5E-03)	1.52E-02 (2.4E-03)	1.48E-02 (2.4E-03)	1.49E-02 (2.4E-03)
π₁₀	2.33E-03 (2.8E-04)	2.45E-03 (2.6E-04)	3.38E-03 (3.1E-04)	1.99E-03 (2.3E-04)
π₁₁	4.73E-04 (2.0E-04)	2.45E-04 (1.6E-04)	2.88E-04 (1.7E-04)	1.71E-04 (1.3E-04)

Column definition: LRT - likelihood ratio test; FNK BMD - femoral neck bone mineral density; HDL - high density lipoprotein cholesterol; LDL - low density lipoprotein cholesterol; TC - total cholesterol; TG - triglyceride. The two rows provided LRT statistics and p-values of hypothesis testing respectively; π₀₀ indicates the proportion of the SNP associated with neither of the two phenotypes; π₀₁ and π₁₀ indicate the proportion of the SNP associated with only one of the two phenotypes; π₁₁ indicates the proportion of the SNP associated with both of the two phenotypes; The values in the brackets are standard errors of the estimates.