Table 5.
Quadratic change cluster summary. Clusters (cluster forming threshold, p < 0.05; clusters for multiple comparisons, p < 0.05) showing PAE vs. Control by quadratic age interactions% change in dependent measure controlling for study site.
| A. CT | |||||||
|---|---|---|---|---|---|---|---|
| Cluster Number | Cerebral Hemisphere | Anatomical Location | Size (mm2) | Number of vertices | Peak vertex MNI (x,y,z) | Clusterwise P-value | Findings |
| 9 | Right | Superiorparietal | 2509.18 | 3338 | (14.8, −87.2, 35.1) | 0.00020 | Con < PAE |
| 10 | Left | Precuneus | 1291.62 | 2161 | (−11.4, −71.4, 39.4) | 0.00020 | Con < PAE |
| 11 | Left | Inferiorparietal | 1138.88 | 1772 | (−33.9, −81.4, 29.2) | 0.00040 | Con < PAE |
| B. LGI | |||||||
|---|---|---|---|---|---|---|---|
| Cluster Number | Cerebral Hemisphere | Anatomical Location | Size (mm2) | Number of vertices | Peak vertex MNI (x,y,z) | Clusterwise P-value | Findings |
| 8 | Right | Lateraloccipital | 1027.72 | 1712 | (28.3, −80.3, 14.1) | 0.00020 | Con > PAE |
| 9 | Right | Lateraloccipital | 304.10 | 380 | (23.8, −87.6, −7.1) | 0.039 | Con > PAE |
| 10 | Left | Supramarginal | 1282.00 | 3342 | (−39.7, −27.8, 22.7) | 0.00020 | Con > PAE |
| 11 | Left | Lateraloccipital | 1825.92 | 2810 | (−38.8, −87.3, −4.0) | 0.00020 | Con > PAE |
| 12 | Left | Caudalmiddlefrontal | 632.08 | 1071 | (−37.6, 21.5, 43.8) | 0.00020 | Con > PAE |
| 13 | Left | Lingual | 224.22 | 374 | (−20.5, −59.1, −5.3) | 0.05 | Con > PAE |
| C. Cortical volume | |||||||
|---|---|---|---|---|---|---|---|
| Cluster Number | Cerebral Hemisphere | Anatomical Location | Size (mm2) | Number of vertices | Peak vertex MNI (x,y,z) | Clusterwise P-value | Findings |
| N/A | Right | None | None | None | None | None | None |
| N/A | Left | None | None | None | None | None | None |
NOTE: Con = Control group, PAE = Prenatal Alcohol Exposure group. Monte Carlo Z Simulation test was applied for multiple comparisons. Confidence interval was 90% for all clusters.