Fig. 4.

High-quality embryos inhibit migration of non-decidualized hESCs. a Surface reduction of the migration zone is decreased after co-culturing non-decidualized hESCs with ECM from high-quality embryos (n = 10, i.e., pooled ECM from 50 embryos) compared to control (n = 10, i.e., 50 pooled non-conditioned samples) or low-quality embryos (n = 6, i.e., pooled ECM from 30 embryos). b, c The number of cell divisions (b) or the cell cycle time (c) of non-decidualized hESCs is not different after co-culture with ECM from high-quality embryos (n = 4, i.e., pooled ECM from 20 embryos) compared to control (n = 4, i.e., 20 pooled non-conditioned samples) or low-quality embryos (n = 4, i.e., pooled ECM from 20 embryos). a, b, c Data are expressed as mean ± sem. Values that are significantly different are labeled by asterisks (*p < 0.05; one-way ANOVA). ECM embryo-conditioned medium