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. Author manuscript; available in PMC: 2019 May 9.
Published in final edited form as: Cell Host Microbe. 2018 May 9;23(5):594–606.e7. doi: 10.1016/j.chom.2018.04.001

Figure 5. Nitric Oxide is Protective in Staphylococcal Pneumonia.

Figure 5

(A) Mouse percent mortality of C57BL/6 (black line, n=15) and congenic iNOS−/− (red line, n=15) mice at indicated time points post-infection with S. aureus Newman (~5 × 107 CFU).

Kaplan-Meier plot, *p<0.05.

(B) Mouse body surface temperature, bacterial burden (CFU per lung), and pro-inflammatory cytokines levels of C57BL/6 (black circles, n=10) and congenic iNOS−/− (red circles, n=10) mice measured at 8 h post-infection. Two inocula are indicated for infections with wild-type S. aureus (~5 × 107 or ~1 X 108 CFU) and one inoculum for mice infected with an agr mutant (~5 × 107 CFU).

Individual values are plotted with horizontal lines showing medians of groups, Mann-Whitney U test, *p<0.05.

See also Figure S4–S5.