Table 5.
Effects of Huanglian-Wendan decoction on sucrose solution consumption in CUMS rats.
| Groups | Duration (week) | ||||||
|---|---|---|---|---|---|---|---|
| 0 | 2 | 4 | 6 | 8 | 10 | 12 | |
| Non-CUMS + vehicle | 19.1 ± 0.9 | 20.0 ± 0.6 | 20.7 ± 0.8 | 21.1 ± 1.1 | 22.5 ± 0.8 | 22.5 ± 0.6 | 22.9 ± 0.5 |
| CUMS + vehicle | 19.1 ± 1.2 | 15.8 ± 0.8### | 16.0 ± 0.6### | 15.1 ± 0.6### | 15.4 ± 0.5### | 15.0 ± 0.7### | 15.0 ± 0.7### |
| Huanglian-Wendan decoction (5690 mg/kg) | 19.1 ± 0.9 | 14.3 ± 0.8### | 14.4 ± 0.6### | 14.7 ± 0.8### | 19.4 ± 1.1∗∗ | 20.2 ± 1.4∗∗∗ | 21.0 ± 1.3∗∗∗ |
| Huanglian-Wendan decoction (11,380 mg/kg) | 18.6 ± 0.8 | 15.4 ± 0.8### | 14.6 ± 0.6### | 14.5 ± 0.5### | 17.8 ± 1.2 | 18.6 ± 1.2∗∗ | 20.1 ± 1.0∗∗∗ |
| Fluoxetine (10 mg/kg) | 19.2 ± 0.8 | 14.5 ± 0.5### | 15.0 ± 0.4### | 14.7 ± 0.5### | 20.2 ± 0.3∗∗∗ | 21.6 ± 0.5∗∗∗ | 21.8 ± 0.7∗∗∗ |
All data were expressed as mean ± S.E.M. (n = 12). ###P < 0.001 compared with the non-CUMS group; ∗∗P < 0.01 and ∗∗∗P < 0.001 compared with the CUMS group.