Table 2.
Numbers of PPIs better and less-well-studied genes are involved in
| Database | Better-studied genes |
Less-well-studied
genes |
Difference | ||
|---|---|---|---|---|---|
| Mean n. PPIs | Median n. PPIs | Mean n. PPIs | Median n. PPIs | ||
| BioGRID | 37.8 | 18.0 | 7.2 | 3.0 | P < 2.2 × 10−16 |
| HI-II-14 | 6.8 | 2.0 | 6.2 | 2.0 | P = 0.013 |
| HPRD | 15.2 | 8.0 | 3.4 | 2.0 | P < 2.2 × 10−16 |
| IntAct | 26.4 | 12.0 | 6.5 | 3.0 | P < 2.2 × 10−16 |
Note: Better and less-well-studied genes are defined as those in the top and bottom thirds of genes ranked by the number of related publications in gene2pubmed. Differences tested using a two-sided Mann-Whitney U test.