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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Neuroimage. 2018 Mar 5;174:364–379. doi: 10.1016/j.neuroimage.2018.02.059

Table 1. Regional Changes in CBV Following METH Challenge.

Brain Region Saline (n=17) Meth Early (n=8) Meth Late (n=8) P value

M1 11.80 ± 4.83 15.11 ± 3.87 17.26 ± 9.19 0.1330
M2 11.80 ± 3.91 15.40 ± 2.09 17.69 ± 8.92 0.0053
ILmCx 14.55 ± 4.89 20.81 ± 6.02 25.24 ± 11.38 0.0080
MPFCx 12.83 ± 3.51 15.97 ± 4.31 22.45 ± 8.05 0.0014*
S2 13.44 ± 4.09 13.50 ± 4.47 22.49 ± 6.70 0.0011*
S1BF 9.46 ± 3.85 9.71 ± 5.17 17.54 ± 8.71 0.0110
S1J 14.21 ± 5.98 14.27 ± 5.69 23.08 ± 10.85 0.0300
S1DZ 10.54 ± 4.27 10.36 ± 5.35 17.60 ± 9.48 0.0400
RS Cx 12.63 ± 5.24 14.23 ± 4.03 20.76 ± 10.60 0.0400
CPu 15.11 ± 4.56 15.49 ± 4.61 20.61 ± 6.11 0.0600
ADCPu -6.01 ± 4.13 -5.27 ± 5.16 -1.05 ± 7.46 0.0860
NAc Core 7.17 ± 5.19 4.97 ± 2.63 14.52 ± 6.25 0.0030*
NAc Shell 3.58 ± 4.89 2.76 ± 3.14 13.17 ± 8.09 0.0010*
SN -0.01 ± 3.79 -2.13 ± 4.41 5.64 ± 5.45 0.0066
C-Thal 14.57 ± 7.50 10.89 ± 4.54 24.04 ± 10.88 0.0110
VPL-VPM 2.62 ± 3.18 3.31 ± 3.18 8.04 ± 4.21 0.0060
Septum 0.93 ± 6.73 -1.04 ± 4.80 3.81 ± 6.45 0.3500
Hypothalamus -1.51 ± 4.10 -4.44 ± 2.42 4.81 ± 6.70 0.0011*
Subiculum 11.09 ± 10.21 4.14 ± 2.65 24.57 ± 9.72 0.0007*
DG -8.83 ± 5.51 -8.89 ± 3.00 -4.15 ± 6.69 0.4480
CA1 -2.17 ± 5.73 -7.93 ± 3.71 11.35 ± 7.61 0.0001*
VTA -2.43 ± 1.18 1.59 ± 5.80 2.73 ± 5.00 0.0400
PPTg 7.45 ± 6.21 5.88 ± 2.70 14.19 ± 9.92 0.0700
PN 8.43 ± 8.09 6.87 ± 3.86 22.93 ± 12.31 0.0001*
SC 12.12 ± 7.00 10.29 ± 5.12 16.16 ± 7.37 0.2550
IC 11.30 ± 7.33 9.15 ± 4.46 14.53 ± 7.19 0.3500

Averaged changes in fCBV following challenge with 1mg/kg methamphetamine. M1 – motor cortex area 1, M2 – motor cortex area 2, ILmCx – infralimbic cortex, MPFCx – medial prefrontal cortex, S2 – sensorimotor cortex area 2, S1BF – sensorimotor cortex barrel field, S1J – sensorimotor cortex jaw area, S1DZ – sensorimotor cortex dysgranular region, RS Cx – retrosplenial cortex, CPu – caudate/putamen, AD-CPu – anterior dorsal CPu, NAc Core – nucleus accumbens core region, NAc Shell – nucleus accumbens shell region, SN – substantia nigra, C-Thal – central thalamus, VPL-VPM - ventral posterolateral and ventral posteromedial nuclei of the thalamus, DG – dentate gyrus of the hippocampus, CA1 – CA1 fields of hippocampus, VTA – ventral tegmental area, PPTg - pedunculopontine tegmental nucleus, PN – pontine nucleus, SC – superior colliculus, IC – inferior colliculus.

*

Significant after correction for multiple comparisons using a Bonferroni-Holm.