Table 1. Regional Changes in CBV Following METH Challenge.
Brain Region | Saline (n=17) | Meth Early (n=8) | Meth Late (n=8) | P value |
---|---|---|---|---|
| ||||
M1 | 11.80 ± 4.83 | 15.11 ± 3.87 | 17.26 ± 9.19 | 0.1330 |
M2 | 11.80 ± 3.91 | 15.40 ± 2.09 | 17.69 ± 8.92 | 0.0053 |
ILmCx | 14.55 ± 4.89 | 20.81 ± 6.02 | 25.24 ± 11.38 | 0.0080 |
MPFCx | 12.83 ± 3.51 | 15.97 ± 4.31 | 22.45 ± 8.05 | 0.0014* |
S2 | 13.44 ± 4.09 | 13.50 ± 4.47 | 22.49 ± 6.70 | 0.0011* |
S1BF | 9.46 ± 3.85 | 9.71 ± 5.17 | 17.54 ± 8.71 | 0.0110 |
S1J | 14.21 ± 5.98 | 14.27 ± 5.69 | 23.08 ± 10.85 | 0.0300 |
S1DZ | 10.54 ± 4.27 | 10.36 ± 5.35 | 17.60 ± 9.48 | 0.0400 |
RS Cx | 12.63 ± 5.24 | 14.23 ± 4.03 | 20.76 ± 10.60 | 0.0400 |
CPu | 15.11 ± 4.56 | 15.49 ± 4.61 | 20.61 ± 6.11 | 0.0600 |
ADCPu | -6.01 ± 4.13 | -5.27 ± 5.16 | -1.05 ± 7.46 | 0.0860 |
NAc Core | 7.17 ± 5.19 | 4.97 ± 2.63 | 14.52 ± 6.25 | 0.0030* |
NAc Shell | 3.58 ± 4.89 | 2.76 ± 3.14 | 13.17 ± 8.09 | 0.0010* |
SN | -0.01 ± 3.79 | -2.13 ± 4.41 | 5.64 ± 5.45 | 0.0066 |
C-Thal | 14.57 ± 7.50 | 10.89 ± 4.54 | 24.04 ± 10.88 | 0.0110 |
VPL-VPM | 2.62 ± 3.18 | 3.31 ± 3.18 | 8.04 ± 4.21 | 0.0060 |
Septum | 0.93 ± 6.73 | -1.04 ± 4.80 | 3.81 ± 6.45 | 0.3500 |
Hypothalamus | -1.51 ± 4.10 | -4.44 ± 2.42 | 4.81 ± 6.70 | 0.0011* |
Subiculum | 11.09 ± 10.21 | 4.14 ± 2.65 | 24.57 ± 9.72 | 0.0007* |
DG | -8.83 ± 5.51 | -8.89 ± 3.00 | -4.15 ± 6.69 | 0.4480 |
CA1 | -2.17 ± 5.73 | -7.93 ± 3.71 | 11.35 ± 7.61 | 0.0001* |
VTA | -2.43 ± 1.18 | 1.59 ± 5.80 | 2.73 ± 5.00 | 0.0400 |
PPTg | 7.45 ± 6.21 | 5.88 ± 2.70 | 14.19 ± 9.92 | 0.0700 |
PN | 8.43 ± 8.09 | 6.87 ± 3.86 | 22.93 ± 12.31 | 0.0001* |
SC | 12.12 ± 7.00 | 10.29 ± 5.12 | 16.16 ± 7.37 | 0.2550 |
IC | 11.30 ± 7.33 | 9.15 ± 4.46 | 14.53 ± 7.19 | 0.3500 |
Averaged changes in fCBV following challenge with 1mg/kg methamphetamine. M1 – motor cortex area 1, M2 – motor cortex area 2, ILmCx – infralimbic cortex, MPFCx – medial prefrontal cortex, S2 – sensorimotor cortex area 2, S1BF – sensorimotor cortex barrel field, S1J – sensorimotor cortex jaw area, S1DZ – sensorimotor cortex dysgranular region, RS Cx – retrosplenial cortex, CPu – caudate/putamen, AD-CPu – anterior dorsal CPu, NAc Core – nucleus accumbens core region, NAc Shell – nucleus accumbens shell region, SN – substantia nigra, C-Thal – central thalamus, VPL-VPM - ventral posterolateral and ventral posteromedial nuclei of the thalamus, DG – dentate gyrus of the hippocampus, CA1 – CA1 fields of hippocampus, VTA – ventral tegmental area, PPTg - pedunculopontine tegmental nucleus, PN – pontine nucleus, SC – superior colliculus, IC – inferior colliculus.
Significant after correction for multiple comparisons using a Bonferroni-Holm.