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. Author manuscript; available in PMC: 2019 Jun 5.
Published in final edited form as: J Pharm Biomed Anal. 2018 Apr 5;155:241–246. doi: 10.1016/j.jpba.2018.04.002

Fig. 2.

Fig. 2

Indirect drug effect of the antimalarial lumefantrine (LF) on parasite clearance stratified by burden of infection. The figures depict a pharmacokinetic-pharmacodynamic profile of parasite clearance time and LF exposure stratified by participants with low (below the median) and high (equal to or above the median) initial parasite densities. Adjusted for age and sex, children with parasitemia lower than the median cleared parasites 13.4 h faster for each magnitude increase in LF day 7 concentration (95% confidence interval [CI]: 3.5 to 23.3 h, P<0.01) compared to 2.4 h faster per magnitude increase in those with parasitemia greater than or equal to the median (95% CI: 11.9 to −7.1 h, P=0.61) (F test P=0.03).