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. 2018 May 7;8:149. doi: 10.3389/fonc.2018.00149

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Copyright © 2018 Kunos and Ivy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Triapine–cisplatin–radiation treatment and cell cycle targets. Damaging agents and DNA damage response repair targets are charted in relation to triapine–cisplatin–radiation treatment. Shown in bold are nucleotide supply chain elements likely to be active. *Data suggest M2 or M2b recycling after triapine exposure occurs over an 18-h period, but further validation is needed (21). Pie charts indicate representative 24-h cell cycle effects (22). Abbreviations: APE1, AP endonuclease 1; ATM, ataxia-telangiectasia mutated; ATR, ataxia-telangiectasia and Rad3-related; DNA-PK, DNA-dependent protein kinase; dNTP, deoxynucleotide triphosphate; ERCC1, DNA excision repair protein 1; PARP, poly(ADP-ribose) polymerase; RNR, ribonucleotide reductase; XP, xeroderma pigmentosum.