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Strategy for ribonucleotide reductase (RNR) inhibitors in cervical or vaginal cancers. The clinical development strategy for RNR-targeted agents like triapine is to block or to stall DNA repair after a maximum amount of inflicted DNA damage occurs during the G1 or S phases of the cell cycle. This strategy is cytotoxic (1) by itself or (2) disrupts homologous recombination repair.
