Table 3.

Log(NT-proBNP) and lobar gray matter volume in the CARDIA brain magnetic resonance imaging sample.

Dependent variable	βa	95% CI	p-Value
Temporal lobe gray matter (mL)
Model 1	−1.31	−2.13, −0.49	0.002
Model 2	−1.27	−2.11, −0.43	0.003
Model 3	−1.10	−1.20, −0.21	0.015
Frontal lobe gray matter (mL)
Model 1	−0.94	−1.84, −0.032	0.043
Model 2	−0.90	−1.83, 0.035	0.059
Model 3	−0.75	−1.76, 0.28	0.144
Parietal lobe gray matter (mL)
Model 1	−0.54	−1.10, 0.03	0.063
Model 2	−0.57	−1.15, 0.014	0.056
Model 3	−0.52	−1.14, 0.11	0.104
Occipital lobe gray matter (mL)
Model 1	−0.26	−0.84, 0.31	0.36
Model 2	−0.28	−0.82, 0.25	0.30
Model 3	−0.19	−0.75, 0.38	0.51

Model 1: adjusted for age, sex, race, and intracranial volume.

Model 2: Model 1 covariates + smoking status, anti-hypertension medication use, systolic blood pressure, diastolic blood pressure, cardiovascular history, renal history, body mass index, total cholesterol, glomerular filtration rate, education, and exam center.

Model 3: Model 2 covariates + cardiac output.

^aCoefficient represents the difference in brain tissue volume (milliliter) corresponding to 1 unit increase in log NT-proBNP (picograms/milliliter).