Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 7;5:129. doi: 10.3389/fmed.2018.00129

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Schubert, Johnson, Marks and Devine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Current molecular model of signaling triggered by ultraviolet (UV)/riboflavin (MIRASOL) and UV/amotosalen (INTERCEPT) in platelets: UV can penetrate either directly or via surface/receptor proteins to activate p38MAPK kinase as one of the central players in the signaling cascade. Thus far it has been shown that p38 activation/phosphorylation (P-p38) is involved in regulating (1) degranulation, (2) release of free mitochondria, (3) the modulation of glycoproteins (GPs), (4) the expression levels of mRNAs and potentially protein synthesis, (5) microvesicle (MVs) release, and (6) the development of apoptosis via proapoptotic protein expression and caspase activation. This figure was modified from Ref. (150).