Figure 1.

Pathophysiologically relevant microRNAs (miRNAs) in graft-versus-host disease with a functional role in T-cell development, homeostasis, and differentiation. miRNAs adjacent to arrows indicate those miRNAs that positively contribute to intrathymic development (left), proliferation and/or homeostasis (center), or differentiation of T cell subsets. miRNAs highlighted in green mirror exert major functions. Loss of these miRNAs partially mirrors depletion of all miRNAs in mice. miRNAs highlighted in red indicate miRNAs with non-dominant functions. For details, see text. Abbreviations: NKT, natural killer T cell; Treg, regulatory T cell; Tconv, conventional T cell; Th, T helper cell.