Table 1.

MicroRNAs (miRNAs) acting in T cells, for which a role in graft-versus-host disease (GvHD) has been established in preclinical models.

miRNA	Physiologic function	Role in GvHD	Reference
miR-17–92	Promotes early T-cell development Promotes activation-dependent T-cell proliferation Regulates regulatory T cell (Treg) cell suppressive function	Pathogenic	(60–65)
miR-142	Curtails T-cell progenitor numbers Promotes T-cell proliferation	Pathogenic	(47, 66)
miR-146a	Promotes Treg-cell homeostasis	Beneficial	(67–69)
miR-146b	n.d.	Pathogenic	(70)
miR-153-3p	Prevents immunosuppression through indoleamine-2,3-dioxygenase	Pathogenic	(71, 72)
miR-155	Promotes Treg cell homeostasis	Pathogenic	(73, 74)
miR-181a	Rheostat for T-cell receptor signaling Promotes development of invariant natural killer T cells	Beneficial	(75–84)