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. 2018 May 7;9:987. doi: 10.3389/fimmu.2018.00987

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Copyright © 2018 Ma, Sun, Sun, Chen, Wei, Yu, Liu, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gamma-aminobutyric acid (GABA) promotes leukocyte infiltration in DSS-induced colitis in mice. (A) Representative immunohistochemical data of CD-45 staining in colon mucosa of mice with or without GABA treatment. Leukocyte infiltration (brown) in the distal colon mucosa increased after DSS treatment compared with the control group, and further increment in leukocyte infiltration were obtained in response to GABA or muscimol co-treatment. These changes were reduced by treatment with bicuculline, scale bar 100 μm. (B) Bar graphs depicting inflammatory severity within the different groups (n = 8 per group). ***P < 0.001 vs. control group; ^###P < 0.001 vs. the DSS group; ^$$$P < 0.001 vs. the DSS + GABA group.