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. 2018 May 7;9:987. doi: 10.3389/fimmu.2018.00987

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Copyright © 2018 Ma, Sun, Sun, Chen, Wei, Yu, Liu, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gamma-aminobutyric acid (GABA) inhibits mucous secretion. Mice receiving a 3% solution of DSS in their drinking water (ad libitum) were treated with or without GABA, a GABA_A receptor agonist or an antagonist and euthanized on day 3. (A) Representative staining of mucous layers (blue) within the different groups, scale bar 50 μm. (B) Representative immunohistochemical staining of muc-2 (brown) in colon mucosa within the different groups, scale bar 50 μm. (C) Bar graphs depicting the number of muc-2-positive cells in one crypt within the different groups. ***P < 0.001 vs. control group; ^##P < 0.01, ^###P < 0.001 vs. the DSS group; ^$$$P < 0.001 vs. the DSS + GABA group.