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. 2018 May 7;9:473. doi: 10.3389/fphys.2018.00473

FIGURE 1.

FIGURE 1

Treatment with liposome-encapsulated clodronate (LEC) reduced systolic blood pressure (SBP) in the angiotensin (Ang) II mice (A) and DS rats (B) and attenuated the ratio of albuminuria/creatinine (C) in the Ang II mice. Quantification of monocyte, lymphocyte, and granulocyte population in the circulating peripheral blood smear stained with Giemsa in Ang II mice (D) and hypertensive DS rats (E). Ctr, control mice treated with PBS liposome; LEC, normal mice treated with LEC; Ang II, the mice treated with Ang II (1400 ng/min/mg body weight); Ang/LEC, the mice treated with Ang II plus LEC treatment; NS, DS rats fed a normal salt (0.5% NaCl) diet; HS, DS rats fed a HS (4% NaCl) diet. N = 8, ∗p < 0.05, vs. control group or NS group, #p < 0.05, vs. Ang II group or HS group.