Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 May 7;9:944. doi: 10.3389/fimmu.2018.00944

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Guo, Zhao, Wu, Tao, Zhang, Zhao, Yang, Jiang, Wang, Sun, Li, Li and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Increases in the percentages of circulating T follicular helper (Tfh)-like and B cells in relapsing-remitting MS (RR-MS) patients during the relapsing phase of the disease. Representative flow cytometry results of CD3⁺CD4⁺CXCR5⁺PD-1⁺ Tfh-like cells (A) and B cells (B) in healthy controls (HCs), relapsing and remitting patients. Numbers in the upright corner illustrated the percentage of CXCR5⁺PD-1⁺ cells in CD4⁺ T cells and the percentage of CD19⁺ B cells in lymphocytes. Comparisons of the frequencies of Tfh-like cells (C) and B cells (D) among HCs, relapsing patients and remitting patients. (E) Comparison of serum IL-21 level among HCs, relapsing patients, and remitting patients. (F) The correlation analysis between the frequency of Tfh-like cells and the frequency of B cells in patients with RR-MS. (G) The correlation analysis between the frequency of Tfh-like cells and serum IL-21 level in patients with RR-MS. (H) The correlation analysis between the frequency of B cells and serum IL-21 level in patients with RR-MS. Each data point represents an individual subject. The horizontal lines represent the mean values. HCs: n = 20; relapsing patients, n = 13; remitting patients, n = 15. *P < 0.05, **P < 0.01, ***P < 0.001.