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. 2018 May 7;9:762. doi: 10.3389/fimmu.2018.00762

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Copyright © 2018 Bai, He, Liu, Zhang, Li, Shi, Wang, Han, Zhang, Zhang, Cai and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Direct interaction between Notch signaling and SIRT1 in macrophages. (A) RAW264.7 cells were treated with 1 µg/ml lipopolysaccharide (LPS), and then RT-PCR was used to examine the time-dependent expression of Notch1, Notch2, and Hes1. **p < 0.01 compared with 0 h; n = 6. (B) Co-immunoprecipitation of intracellular domain of Notch (NICD) and SIRT1. RAW264.7 cells were stimulated with LPS and then the cell extracts were used for immunoprecipitation (IP) with anti-NICD antibody and immunoblotting with anti-SIRT1 antibody, and for IP with anti-SIRT1 antibody and immunoblotting with anti-NICD antibody; n = 4.