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. 2018 May 7;9:762. doi: 10.3389/fimmu.2018.00762

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Copyright © 2018 Bai, He, Liu, Zhang, Li, Shi, Wang, Han, Zhang, Zhang, Cai and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RBP-J knockout led to decreased inflammation in macrophages. (A) RBP-J^−/− and wild-type (WT) macrophages were stimulated with lipopolysaccharide (LPS) and then RT-PCR was used to assess the levels of IL-1β, IL-6, TNF-α, CCL2, and NOS2. (B) RBP-J^−/− and WT macrophages were treated with LPS or PBS and then the phosphorylation levels of p65 and IκBα were examined through Western blotting. **p < 0.01 compared with LPS + WT group; n = 6.