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. 2018 May 7;9:762. doi: 10.3389/fimmu.2018.00762

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Copyright © 2018 Bai, He, Liu, Zhang, Li, Shi, Wang, Han, Zhang, Zhang, Cai and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RBP-J knockout resulted in decreased inflammation in vivo. (A) Survival rates of wild-type (WT) and RBP-J^−/− mice after 72-h stimulation with lipopolysaccharide (LPS). (B) IL-1β, IL-6, and TNF-α levels in blood were measured using a microplate reader. (C) Hematoxylin and eosin staining of heart, liver, lung, and kidney tissues from RBP-J^−/− and WT mice after peritoneal injection of LPS. Sections were examined and photographed under a microscope. (D) Levels of creatinine (Cr), blood urea nitrogen (BUN), alanine aminotransferase (ALT), and aspartate transaminase (AST) in blood were determined using commercial ELISA kits. **p < 0.01 compared with WT mice; n = 6. Scale bar = 50 µm.