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Sirt1-Notch interaction in lipopolysaccharide (LPS)-induced macrophages. In LPS-induced inflammation, SIRT1 was suppressed, and Notch signaling was activated. SIRT1 caused the deacetylation of intracellular domain of Notch (NICD), which led to NICD degradation and inhibition of Notch signaling. The inactivation of Notch signaling reduced the activation of the NF-κB pathway in inflammation.
