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. 2018 May 7;9:996. doi: 10.3389/fimmu.2018.00996

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Copyright © 2018 Calise, Marquez Renteria, Gregersen and Diamond.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interferon regulatory factor 5 (IRF5) risk alleles do not affect induced IRF5 expression in B cells. Purified B cells were stimulated with toll-like receptor agonists CpG or R848 for the indicated times and subjected to qPCR for CD86 (A) or IRF5 (B,C) IRF5 qPCR. Results are shown combined (B) and separated by haplotype (C). Unstimulated cell expression values are normalized to 1.0. p < 0.05, p < 0.01, and p < 0.0001 by Friedman test with Dunn’s multiple comparisons test (A,B), p = ns by Wilcoxon matched-pairs signed rank test for each treatment (C).