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. 2018 May 7;9:996. doi: 10.3389/fimmu.2018.00996

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Copyright © 2018 Calise, Marquez Renteria, Gregersen and Diamond.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Susceptibility to apoptosis in B cells does not differ according to interferon regulatory factor 5 haplotype. Fresh peripheral blood mononuclear cells (PBMCs) were treated with 50 mM CPT-11 for 8 h, stained for CD19, CD14, viability dye, active caspase 3, and analyzed by flow cytometry. (A) Representative dot plots of vehicle and CPT-11-treated PBMCs. (B) Representative dot plots showing proportions of caspase 3⁺ B cells (top row) and monocytes (bottom row) in risk (left column) and non-risk (right column) haplotype subjects. (C) Proportion of apoptotic CD19⁺ cells shown combined (top) and separated by haplotype (bottom). (D) Apoptotic CD14⁺ monocytes shown combined (top) and separated by haplotype (bottom). p < 0.0001 by Wilcoxon matched-pairs signed rank test [(C,D), top], p = ns by Mann–Whitney test for each treatment [(C), bottom], p < 0.05 by Mann–Whitney test for each treatment [(D), bottom].