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. 2018 May 7;9:939. doi: 10.3389/fimmu.2018.00939

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Copyright © 2018 Aarão, de Sousa, Falcão, Falcão and Quaresma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nerve growth factor (NGF) signaling cascade. NGF is produced during development and into maturity by immune and nerve cells as well as peripheral effector cells, such as keratinocytes, melanocytes, and fibroblasts. NGF exhibits high affinity to receptor TrkA and low affinity to receptor p75. The binding of NGF through receptor TrkA induces autophosphorylation of TrkA receptor and activation of P13K/Akt pathway leading to neuronal differentiation, survival, and neurite. NGF binding to receptor p75 activate c-Jun kinase (JNK) and NF-κB pathways resulting in neuronal apoptosis and survival respectively.