Table 1.
Allergen immunotherapy-like desensitization schedule for cytarabine-induced delayed hypersensitivity
Step* | Solution [mg/ml] | Total volume injected [ml] | Number of injections** | Dose [mg] |
---|---|---|---|---|
1 | 0.2 | 0.2 | 2 | 0.04 |
2 | 0.2 | 1 | 4 | 0.2 |
3 | 2 | 0.3 | 3 | 0.6 |
4 | 2 | 0.5 | 3 | 1 |
5 | 2 | 1 | 4 | 2 |
6 | 2 | 2.4 | 4 | 4.8 |
7 | 20 | 0.5 | 4 | 10 |
8 | 20 | 1 | 4 | 20 |
9 | 100 | 0.3 | 3 | 30 |
10 | 100 | 0.4 | 4 | 40 |
11 | 100 | 0.6 | 3 | 60 |
12 | 100 | 0.8 | 4 | 80 |
Total | 42 | 248.64 |
Desensitization sessions were performed every other day (with few exceptions; e.g. patient availability, week-end days etc.).
Two to four subcutaneous injections were given 30 min apart during the same desensitization session.