Table 4.
Univariate analysis of clinical features in successful and adverse pregnancy outcome (APO) pregnancies.
| Clinical/serological features | APO (n = 50) (17.7%) | Successful pregnancies (n = 233) (82.3%) | p-Value | OR (CI 95%) |
|---|---|---|---|---|
| Age at the onset ≥35 years (n = 107) | 20/50 (40) | 87/233 (37.3) | NS | _ |
| Formal diagnosis of antiphospholipid syndrome (APS) (n = 190) | 38/50 (76) | 152/233 (65.2) | NS | – |
| Organ-specific autoimmune diseasea (n = 38) | 12/50 (24) | 26/233 (11.2) | 0.016e | 2.51 (1.09–5.75) |
| Previous thrombosis (n = 66) | 16/50 (32) | 50/233 (21.5) | NS | – |
| Previous pregnancy morbidity (n = 151) | 27/50 (54) | 124/233 (53.2) | NS | – |
| Previous premature birth (n = 32) | 10/50 (20) | 22/233 (9.4) | 0.032f | 2.39 (0.99–5.82) |
| Previous ≥3 spontaneous abortion (n = 29) | 4/50 (8) | 25/233 (10.7) | NS | – |
| Prior pregnancy morbidity and thrombosis (n = 27) | 5/50 (10) | 22/233 (9.4) | NS | – |
| Other APS-related manifestationsb (n = 48) | 16/50 (32) | 32/233 (13.7) | 0.002f | 2.95 (1.38–6.29) |
| Acquired risk factors for thrombosisc (n = 90) | 21/50 (42) | 69/233 (29.6) | NS | – |
| Inherited thrombophilia (data available for 237 pregnancies)d (n = 23) | 5/40 (12.5) | 18/197 (9.1) | NS | – |
aAssociated autoimmune organ disease, thyroiditis, autoimmune hepatitis, primary biliary cirrhosis, psoriasis, celiac disease.
bOther APS-related manifestations, thrombocytopenia, epilepsy, headache, livedo reticularis, heart valve lesions, and hemolytic anemia.
cAcquired risk factors for thrombosis, hypertension, BMI >30 kg/m2, and smoke.
dInherited thrombophilia, factor II and factor V mutation, protein C and S and antithrombin III deficiency.
NS, not statistically significant.
eSignificant at multivariate analysis, p = 0.012 (OR 3.29, CI 95% 1.29–8.38).
fNot significant at multivariate analysis.