Table 1. Biological Data of Compounds from Scheme 1.

compd. No.	CXCR4 Ca2+ flux IC50 (nM)	microsomal stability (H/R/M)a	CYP450 2D6 IC50 (μM)b	PAMPA pH 7.4 Pc (nm/s)
5	6	77/37/17	0.32	0
13	65	86/65/13	1.87	0
14	150	66/17/32	1.04	19
15	553	96/62/79	4.21	10
16	17	100/100/92	2.14	0
17	66	82/15/96	1.43	14
20	161	75/28/23	0.03	0
21	16	93/55/56	0.11	55

^aLiver microsomal stability measured as percent remaining by LCMS after 10 min in human (H), rat (R), and mouse (M) microsomes.

^bAll compounds have mAChR Ca²⁺ flux IC₅₀ > 14 μM and CYP450 3A4 IC₅₀ > 12 μM.