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(a) Real time kinetic responses of 63 at different doses in HT-29 cells. (b) DMR amplitudes of compound 63 as a function of doses compared with the dose-dependent desensitization of zaprinast DMR by 63, and the dose-dependent inhibition of the DMR of 100 nM compound 63 by compound 5. The data represents mean ± sd from two independent measurement, each with four replicates (n = 8).
