Table 1. Antiproliferation Activities for 2–6 against Nine Solid Cancer Cell Linesa.
| IC50 (nM) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| compd | HeLa | SKOV3 | A549 | OVCA429 | OVCA433 | A2780 | MDA-MB-231 | MCF-7 | KB |
| 15 | 8826 | 3909 | 4778 | 5173 | 4389 | 1635 | 1233 | 3503 | 3691 |
| 1 | 62.2 | 47.3 | 45.8 | 41.1 | 130.8 | 20.9 | 85.9 | 445 | 127 |
| 2 | 22.9 | 17.3 | 2.0 | 1.7 | 1.1 | 12.7 | 6.0 | 2351 | 4542 |
| 3 | 2.8 | 8.3 | 3.7 | 3.9 | 3.3 | 6.6 | 0.8 | 2853 | 3234 |
| 4 | 15.4 | 19.2 | 7.9 | 6.1 | 16.3 | 10.2 | 1.1 | 3131 | 1143 |
| 5 | 17.8 | 35.8 | 3.3 | 4.4 | 10.1 | 8.7 | 0.5 | 1865 | 2182 |
| 6 | 6.9 | 25.0 | 3.5 | 4.0 | 6.6 | 14.5 | 1.4 | 1413 | 1665 |
| cisplatin | 2741 | 1440 | 13220 | 7296 | 24630 | 2549 | NA | NA | NA |
| doxorubicin | NA | NA | NA | NA | NA | NA | NA | 879 | NA |
| gemcitabine | NA | NA | NA | NA | NA | NA | 36.4 | NA | NA |
| vincristine | NA | NA | NA | NA | NA | NA | NA | NA | 0.65 |
a
MTT assay. The data are the mean of triplicate determinations. NA: not available. HeLa: human cervical cancer cell lines. SKOV3, OVCA429, OVCA433 and A2780: human ovarian cancer cell lines. A549: human nonsmall cell lung cancer cell lines. MDA-MB-231 and MCF-7: human breast cancer cell lines. KB: human oral epidermoid cancer cell lines.