Table 2. Antiproliferation Activities for 2–6 in Hematological Tumor Cell Linesa.
IC50 (nM) | 1 | 2 | 3 | 4 | 5 | 6 | SAHA | lenalidomide | CC-885 |
---|---|---|---|---|---|---|---|---|---|
MV-4–11 | 28.3 | 24.5 | 27.2 | 66.3 | 29.3 | 29.6 | NA | >20000 | 0.3 |
MM-1S | 21.0 | 12.0 | 143.0 | 24.0 | 28.0 | 25.0 | 2844 | NA | NA |
MTS assay. The data are the mean of triplicate determinations. NA: not available. MV-4–11: human myeloid leukemia cell lines. MM-1S: human myeloma cell lines.