Table 4. Antiproliferation Activities for 2–6 in Nontumorigenesis Cells.
| IC50 (μM) | 1 | 2 | 3 | 4 | 5 | 6 | cisplatin | lenalimide | CC-885 |
|---|---|---|---|---|---|---|---|---|---|
| HUVECa | 0.13 | 0.44 | 0.27 | 0.19 | 0.41 | 0.36 | 1.10 | NA | NA |
| T29a | 1.8 | >5 | >5 | >5 | 2.5 | 3.5 | 1.8 | NA | NA |
| WI-38b | 0.09 | >20 | >20 | 1.36 | 0.44 | 0.56 | NA | >20 | >20 |
| MCF-10Ab | 0.66 | >20 | >20 | NA | NA | NA | NA | >20 | 0.005 |
a
MTT assay.
b
MTS assay. The data are the mean of triplicate determinations. NA: not available. HUVEC: human umbilical vein endothelial cell lines. T29: human immortalized but nontumorigenic ovarian epithelial cell lines. WI-38: human lung fibroblasts. MCF-10A: human nontumorigenic breast epithelial cell lines.