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. 2015 Jun 17;6(10):5601–5616. doi: 10.1039/c5sc00951k

Biodistribution data for 99mTc-labeled PNA derivatives performed in healthy male Wistar rats at 5 min and 60 min after single intravenous injection. Data are presented as SUV.

17-mer [99mTc](Tc-Dpa)-PNA 17-mer [99mTc](Tc-Dpa)-(Cys-PEG2kDa)-PNA 17-mer [99mTc](Tc-Dpa)-(Cys-PEG10kDa)-PNA
5 min p.i. (n = 12) 60 min p.i. (n = 11) 5 min p.i. (n = 8) 60 min p.i. (n = 8) 5 min p.i. (n = 8) 60 min p.i. (n = 8)
Blood 1.36 ± 0.21 0.24 ± 0.10 1.51 ± 0.13 0.24 ± 0.06 2.01 ± 0.38 0.34 ± 0.11
Kidneys 11.7 ± 1.60 13.1 ± 1.99 12.0 ± 1.42 9.29 ± 1.10 11.3 ± 1.86 9.75 ± 2.64
Adrenals 0.56 ± 0.12 0.14 ± 0.04 0.80 ± 0.25 0.32 ± 0.21 0.82 ± 0.15 0.25 ± 0.08
Liver 0.91 ± 0.23 0.85 ± 0.26 1.12 ± 0.42 0.98 ± 0.42 1.15 ± 0.21 0.73 ± 0.30
Spleen 0.59 ± 0.31 0.22 ± 0.04 0.92 ± 0.29 0.71 ± 0.34 0.60 ± 0.13 0.54 ± 0.46
Pancreas 0.51 ± 0.30 0.14 ± 0.16 0.35 ± 0.04 0.26 ± 0.25 0.51 ± 0.06 0.61 ± 1.24
Thymus 0.46 ± 0.09 0.10 ± 0.02 0.46 ± 0.08 0.10 ± 0.01 0.45 ± 0.06 0.12 ± 0.04
Muscles 0.38 ± 0.16 0.05 ± 0.01 0.35 ± 0.03 0.09 ± 0.04 0.30 ± 0.08 0.13 ± 0.09
Lung 1.06 ± 0.18 0.22 ± 0.06 2.30 ± 0.69 2.16 ± 1.36 1.41 ± 0.24 0.42 ± 0.16
Heart 0.58 ± 0.07 0.10 ± 0.04 0.64 ± 0.06 0.13 ± 0.04 0.81 ± 0.21 0.17 ± 0.06
Femur 0.56 ± 0.03 0.16 ± 0.02 0.45 ± 0.01 0.14 ± 0.03 0.51 ± 0.07 0.16 ± 0.04
Testicles 0.25 ± 0.13 0.09 ± 0.02 0.34 ± 0.14 0.13 ± 0.03 0.34 ± 0.08 0.16 ± 0.03
Hadrian glands 0.57 ± 0.08 0.12 ± 0.03 0.58 ± 0.18 0.18 ± 0.15 0.59 ± 0.09 0.17 ± 0.04
Brain 0.04 ± 0.01 0.01 ± 0.00 0.04 ± 0.00 0.02 ± 0.02 0.07 ± 0.02 0.01 ± 0.01
Hair & Skin 0.79 ± 0.07 0.24 ± 0.11 0.93 ± 0.08 0.24 ± 0.03 0.86 ± 0.19 0.28 ± 0.07