Biodistribution data for 99mTc-labeled PNA derivatives performed in healthy male Wistar rats at 5 min and 60 min after single intravenous injection. Data are presented as SUV.
17-mer [99mTc](Tc-Dpa)-PNA | 17-mer [99mTc](Tc-Dpa)-(Cys-PEG2kDa)-PNA | 17-mer [99mTc](Tc-Dpa)-(Cys-PEG10kDa)-PNA | ||||
---|---|---|---|---|---|---|
5 min p.i. (n = 12) | 60 min p.i. (n = 11) | 5 min p.i. (n = 8) | 60 min p.i. (n = 8) | 5 min p.i. (n = 8) | 60 min p.i. (n = 8) | |
Blood | 1.36 ± 0.21 | 0.24 ± 0.10 | 1.51 ± 0.13 | 0.24 ± 0.06 | 2.01 ± 0.38 | 0.34 ± 0.11 |
Kidneys | 11.7 ± 1.60 | 13.1 ± 1.99 | 12.0 ± 1.42 | 9.29 ± 1.10 | 11.3 ± 1.86 | 9.75 ± 2.64 |
Adrenals | 0.56 ± 0.12 | 0.14 ± 0.04 | 0.80 ± 0.25 | 0.32 ± 0.21 | 0.82 ± 0.15 | 0.25 ± 0.08 |
Liver | 0.91 ± 0.23 | 0.85 ± 0.26 | 1.12 ± 0.42 | 0.98 ± 0.42 | 1.15 ± 0.21 | 0.73 ± 0.30 |
Spleen | 0.59 ± 0.31 | 0.22 ± 0.04 | 0.92 ± 0.29 | 0.71 ± 0.34 | 0.60 ± 0.13 | 0.54 ± 0.46 |
Pancreas | 0.51 ± 0.30 | 0.14 ± 0.16 | 0.35 ± 0.04 | 0.26 ± 0.25 | 0.51 ± 0.06 | 0.61 ± 1.24 |
Thymus | 0.46 ± 0.09 | 0.10 ± 0.02 | 0.46 ± 0.08 | 0.10 ± 0.01 | 0.45 ± 0.06 | 0.12 ± 0.04 |
Muscles | 0.38 ± 0.16 | 0.05 ± 0.01 | 0.35 ± 0.03 | 0.09 ± 0.04 | 0.30 ± 0.08 | 0.13 ± 0.09 |
Lung | 1.06 ± 0.18 | 0.22 ± 0.06 | 2.30 ± 0.69 | 2.16 ± 1.36 | 1.41 ± 0.24 | 0.42 ± 0.16 |
Heart | 0.58 ± 0.07 | 0.10 ± 0.04 | 0.64 ± 0.06 | 0.13 ± 0.04 | 0.81 ± 0.21 | 0.17 ± 0.06 |
Femur | 0.56 ± 0.03 | 0.16 ± 0.02 | 0.45 ± 0.01 | 0.14 ± 0.03 | 0.51 ± 0.07 | 0.16 ± 0.04 |
Testicles | 0.25 ± 0.13 | 0.09 ± 0.02 | 0.34 ± 0.14 | 0.13 ± 0.03 | 0.34 ± 0.08 | 0.16 ± 0.03 |
Hadrian glands | 0.57 ± 0.08 | 0.12 ± 0.03 | 0.58 ± 0.18 | 0.18 ± 0.15 | 0.59 ± 0.09 | 0.17 ± 0.04 |
Brain | 0.04 ± 0.01 | 0.01 ± 0.00 | 0.04 ± 0.00 | 0.02 ± 0.02 | 0.07 ± 0.02 | 0.01 ± 0.01 |
Hair & Skin | 0.79 ± 0.07 | 0.24 ± 0.11 | 0.93 ± 0.08 | 0.24 ± 0.03 | 0.86 ± 0.19 | 0.28 ± 0.07 |