Comparison of 99mTc activity concentration of radiolabeled 17-mer PNA conjugates of current studies with previously published 12-mer PNA48 in healthy male Wistar rats at 5 min and 60 min after single intravenous injection. Data are presented as SUV.
| 12-mer [99mTc]-(Tc-Dpa)-PNA from ref. 48 | 17-mer [99mTc]-(Tc-Dpa)-PNA | 17-mer [99mTc](Tc-Dpa)-(Cys-PEG2kDa)-PNA | 17-mer [99mTc](Tc-Dpa)-(Cys-PEG10kDa)-PNA | |
|---|---|---|---|---|
| Blood 5 min p.i. (60 min p.i.) | 1.21 ± 0.05 (0.26 ± 0.10) | 1.36 ± 0.21 (0.24 ± 0.10) | 1.51 ± 0.13 (0.24 ± 0.06) | 2.01 ± 0.38 (0.34 ± 0.11) |
| Kidneys 5 min p.i. (60 min p.i.) | 7.12 ± 0.43 (5.45 ± 0.45) | 11.7 ± 1.60 (13.11 ± 1.99) | 12.0 ± 1.42 (9.29 ± 1.10) | 11.3 ± 1.86 (9.75 ± 2.64) |
| Liver 5 min p.i. (60 min p.i.) | 0.99 ± 0.03 (0.67 ± 0.10) | 0.91 ± 0.23 (0.85 ± 0.26) | 1.12 ± 0.42 (0.98 ± 0.42) | 1.15 ± 0.21 (0.73 ± 0.30) |