. Author manuscript; available in PMC: 2018 May 14.

Published in final edited form as: J Bone Miner Res. 2014 Feb;29(2):275–286. doi: 10.1002/jbmr.2165

Table 1.

Summary of Murine Models of Altered Cx43 Expression

Construct	Cells affected	Cortical phenotype	Trabecular phenotype	Loading response	Unloading response	Reference numbers
Global deletion	All	Cardiac defects, delayed ossification of axial and appendicular skeleton	?	?	?	⁽⁷⁴⁾
Global ODDD mutation	All	Osteopenic: cortical thinning, reduced BMD, reduced strength	Osteopenic	?	?	^(20,21)
DM1-Cre ODDD	Chondro-osteogenic lineage	Osteopenic: cortical thinning, reduced BMD, expanded marrow cavity, reduced strength	None	?	?	⁽²²⁾
DM1-Cre cKO	Chondro-osteogenic lineage	Osteopenic: cortical thinning and marrow expansion, lower BMD	None	↑	?	⁽²²⁾
Col1-Cre cKO	Early osteoblast/osteocyte	Osteopenic: attenuated response to anabolic PTH	Osteopenic	↑	↓	^(31,75,77)
OCN-Cre cKO	Late osteoblast/osteocyte	Osteopenic: increased endosteal BFR, increased osteoclastic bone resorption, increased osteocyte apoptosis	None	↑	↓	^(75,78,79)
Dmp1-Cre cKO	Osteocyte	No change in bone volume, increased cortical area, increased osteocyte apoptosis	None	↑	?	⁽⁷⁹⁾
Global overexpression	All	Cardiac and neural tube defects; skeletal phenotypes have not been examined	?	?	?	⁽²³⁾