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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Semin Thromb Hemost. 2017 May 5;43(6):572–580. doi: 10.1055/s-0037-1599145

Figure 1. Heyde’s syndrome refers to the triad of conditions including aortic stenosis, AVWS, and GI bleeding as a result of angiodysplasia.

Figure 1

In individuals with aortic valve stenosis, the aortic valve can be become narrow causing blood jet. This high flow rate often makes VWF more susceptible to cleavage by ADAMTS13 resulting in the loss of HMWM of VWF and AVWS. Consequently, patients can develop angiodysplasia in the GI tract which can lead to severe and intractable bleeding.