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(A) VEGF-mediated angiogenesis is regulated by extracellular VWF binding integrin αvβ3 to inhibit VEGFR-2 signaling and by intracellular VWF promoting the formation of WPBs to sequester the pro-angiogenic molecule Ang-2. (B) A lack of VWF allows Ang-2 to escapes the cell to promote EC proliferation, motility, and sprouting via signaling of the Tie-2 receptor.
