Table III.

Cox proportional hazard models for the risk of developing ADR

Parameter		Univariate			Multivariate
		Hazard ratio	95% CI	P-value	Hazard ratio	95% CI	P-value
Gender	Female	1.00	–	–	1.00	–	–
	Male	0.9	0.64–1.26	0.53	1.05	0.73–1.50	0.81
Calendar year	2009	1.00	–	–	1.00	–	–
	2010	0.79	0.47–1.34	0.38	0.76	0.44–1.31	0.33
	2011	0.90	0.51–1.60	0.72	0.86	0.47–1.56	0.62
	2012	1.24	0.78–1.97	0.36	1.11	0.67–1.84	0.68
	2013	1.52	0.95–2.43	0.08	1.17	0.63–2.16	0.62
Age	With each 5-year increase	1.02	1.00–1.03	0.01	1.08	1.01–1.16	0.02
	With each 10-year increase	1.18	1.04–1.35	0.01	1.17	1.03–1.34	0.02
NRTI	AZT/3TC	1.00	–	–	1.00	–	–
	TDF/FTC	0.95	0.51–1.76	0.87	0.91	0.46–1.81	0.79
Regimen	2 ARVs	1.00	–	–	1.00	–	–
	3 ARVs	1.33	0.95–1.86	0.10	1.22	0.75–1.99	0.41
Exposure risk	Sexual	1.00	–	–	1.00	–	–
	Needle stick	1.10	0.74–1.63	0.64	0.98	0.62–1.54	0.92
	Other	0.82	0.52–1.29	0.38	0.80	0.49–1.32	0.39
Source patient HIV status	Unknown	1.00	–	–	1.00	–	–
	HIV infected or high risk	0.85	0.56–1.29	0.45	0.83	0.51–1.33	0.44