Table III.
Changes of parameters of interest before and after atorvastatin treatment within each group (n = 10 each group)
| Variables | Normal – control | High-dose | Low-dose | Without treatment |
|---|---|---|---|---|
| TC [mmol/l] | –0.2 ±0.1 | –0.8 ±0.3* | –0.4 ±0.2 | –0.2 ±0.1 |
| LDL-C [mmol/l] | 0.2 ±0.1 | –0.5 ±0.3* | –0.2 ±0.1 | –0.1 ±0.1 |
| HDL-C [mmol/l] | 0.2 ±0.1 | 0.2 ±0.1 | 0.1 ±0.1 | 0.1 ±0.1 |
| TG [mmol/l] | 0.2 ±0.1 | 0.1 ±0.1 | 0.2 ±0.1 | 0.2 ±0.1 |
| CRP [ng/ml] | 0.2 ±0.1 | –0.8 ±0.4*,# | –0.4 ±0.2& | 0.2 ±0.1 |
| NO [μmol/l] | –0.5 ±0.3 | 1.8 ±1.1*,# | 1.2 ±0.6& | 0.2 ±0.2 |
| ROCK1 [mmol/l] | 11 ±8 | –124 ±65*,# | –72 ±33& | 14 ±7 |
| ALT [U/l] | –2 ±1 | 4 ±2 | 4 ±2 | 2 ±1 |
| CK [U/l] | 2 ±1 | 3 ±2 | 6 ±3 | 4 ±3 |
| Lp-PLA2 [ng/ml] | –0.4 ±0.2 | –3.8 ±1.2*,# | –1.7 ±0.9& | 0.3 ±0.2 |
*
p < 0.05 vs. without-treatment group
#
p < 0.05 vs. low-dose group
&
p < 0.05 vs. without-treatment group
expressed as mean ± SD.