Table 1.
Name of the target | Neurotransmitter system | Biological activity | References |
---|---|---|---|
α7 | Cholinergic | Neuroprotective and anti-inflammatory action | Duris et al.,13 Krafft et al.,14
Han et al.,15 Zou et al.,16 Han et al.,17 Guan et al.,18 Shimohama et al.,19 Kalappa et al.,20 Fujiki et al.,21 Colás et al.22 |
α4β2 | Cholinergic | Inhibition of inflammation | Martin et al.23 |
A1 | Purinergic | Modulation of interleukin release | Burnstock and Boeynaems24 |
A2A | Purinergic | Control of immune cell infiltration after cerebral ischemia | Verkhratsky et al.,25 Puchalowicz et al.,26 Vuorimaa et al.27 |
P2X7 | Purinergic | Neuroprotective activity and modulation of inflammation | Mayne et al.,28 Li et al.,29 Yu et al.,30 Dai and Zhou,31 Troadec et al.,32 Collo et al.,33 Skape et al.34 |
P2X4 | Purinergic | Control of the inflammatory reaction | Suzuki et al.,35 Chu et al.,36 Monif et al.37 |
P2Y12 | Purinergic | Modulation of the inflammatory reaction and platelet aggregation | Melani et al.,38 Vazquez-Villoldo et al.,39 Cavaliere et al.,40 Li et al.41 |
System xc– | Glutamatergic | Control of oxidative stress underlying inflammation | Liu et al.,42 Patel et al.43 |