Table 3.

Distribution of allelic frequencies of the SNPs studied in the TSLP and TLR3 genes after stratification by gender.

Gene SNP	MA	Males		p	p c	OR (95% CI)	Females		p	p c	OR (95% CI)
		Controls (n = 174)	Patients (n = 170)				Controls (n = 191)	Patients (n = 48)
TSLP
rs2289276	T	0.318	0.229	0.013	0.0654		0.299	0.244	0.3079	NS
rs1898671	T	0.366	0.493	0.0013	0.0063	1.68 (1.22–2.31)	0.397	0.453	0.3395	NS
rs10062929	A	0.132	0.038	7.66E-05	0.0003	0.26 (0.12–0.53)	0.113	0.027	0.0167	0.0807	0.20 (0.04–0.85)
rs2289277	G	0.443	0.287	6.13E-05	0.0003	0.26 (0.12–0.53)	0.425	0.333	0.1219	NS
rs2289278	G	0.042	0.054	0.4625	NS		0.053	0.013	0.1287	NS
rs11466749	G	0.145	0.065	0.0016	0.0084	0.26 (0.12–0.53)	0.128	0.090	0.3429	NS
TLR3
rs5743303	T	0.200	0.216	0.6372	NS		0.175	0.188	0.7914	NS
rs5743305	A	0.426	0.348	0.0353	NS		0.410	0.330	0.1562	NS
rs11721827	C	0.066	0.078	0.5152	NS		0.084	0.073	0.5176	NS
rs7657186	A	0.253	0.189	0.0456	NS		0.250	0.208	0.3951	NS
rs13126816	A	0.233	0.291	0.0908	NS		0.264	0.356	0.0870	NS
rs7668666	A	0.280	0.288	0.8200	NS		0.263	0.219	0.3700	NS
rs3775292	C	0.284	0.190	0.0036	0.0282	0.59 (0.41–0.84)	0.258	0.218	0.4277	NS
rs3775291	T	0.286	0.323	0.2899	NS		0.333	0.375	0.4429	NS

SNP: single-nucleotide polymorphism; MA: minor allele; TSLP: thymic stromal lymphopoietin; TLR3: Toll-like receptor 3; OR (95% CI): odds ratio with 95% confidence interval; NS: not significant p > 0.05.

p_c: corrected p value, 10,000-fold permutation testing.